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- Title
Methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is associated with antipsychotic-induced weight gain in first-episode schizophrenia.
- Authors
Srisawat, Umarat; Reynolds, Gavin P.; Zhi Jun Zhang; Xiang Rong Zhang; Arranz, Belen; San, Luis; Dalton, Caroline F.
- Abstract
Genetic variants of the methylenetetrahydrofolate reductase (MTHFR) gene involved in homocysteine metabolism may be important predictors of antipsychotic drug-induced weight gain (AIWG). We tested whether two functional MTHFR polymorphisms are related to AIWG. Weight gain was studied in two cohorts of first-episode, initially drug-naive schizophrenia patients; Chinese Han (n=182) and Spanish Caucasians (? = 72) receiving antipsychotics for 10 wk and 3 months respectively. Blood DNA was genotyped for 677C/T and 1298A/C MTHFR polymorphisms. Patients with the 677 CC genotype had a significantly greater increase in BMI compared to T-allele carriers in both Chinese (p=0.012) and Spanish (p=0.017) samples. The 677C/T MTHFR polymorphism showed an additive effect, but no significant interaction, with the -759C/T HTR2C polymorphism previously associated with AIWG. These results suggest that the 677C/T MTHFR polymorphism might, along with the -759?/? HTR2C poly-morphism and other genetic factors, provide a useful marker for the important and limiting side effect of AIWG.
- Subjects
METHYLENETETRAHYDROFOLATE reductase; ANTIPSYCHOTIC agents; WEIGHT gain; SCHIZOPHRENIA treatment; GENETIC polymorphisms; HOMOCYSTEINE; CYSTEINE metabolism
- Publication
International Journal of Neuropsychopharmacology, 2014, Vol 17, Issue 3, p485
- ISSN
1461-1457
- Publication type
Article
- DOI
10.1017/S1461145713001375