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- Title
High Fischer Ratio Oligopeptides of Gluten Alleviate Alcohol-Induced Liver Damage by Regulating Lipid Metabolism and Oxidative Stress in Rats.
- Authors
Zhao, Penghui; Hou, Yinchen; Chen, Xinyang; Zhang, Mingyi; Hu, Zheyuan; Chen, Lishui; Huang, Jihong
- Abstract
High Fischer ratio oligopeptides (HFOs) exhibit diverse biological activities, including anti-inflammatory and antioxidant properties. HFOs from gluten origin were prepared through fermentation and enzymatic hydrolysis and then characterized using free amino acid analysis and scanning electron microscopy (SEM). Following intervention, the levels of serum total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatic malondialdehyde (MDA) in the rats significantly decreased (p < 0.05). Simultaneously, there was an increasing trend in superoxide dismutase (SOD) levels, and glutathione (GSH) levels were significantly elevated (p < 0.05). The mRNA expression levels of alcohol metabolism-related genes (ADH4, ALDH2, and CYP2E1) exhibited a significant increase (p < 0.05). Histological examination revealed a reduction in liver damage. The findings indicate that high Fischer ratio oligopeptides, prepared through enzymatic and fermentation methods, significantly improve lipid levels, ameliorate lipid metabolism disorders, and mitigate oxidative stress, and exhibit a discernible alleviating effect on alcoholic liver injury in rats.
- Subjects
OLIGOPEPTIDES; LIPID metabolism; OXIDATIVE stress; ALCOHOLIC liver diseases; AMINO acid analysis; ASPARTATE aminotransferase
- Publication
Foods, 2024, Vol 13, Issue 3, p436
- ISSN
2304-8158
- Publication type
Article
- DOI
10.3390/foods13030436