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- Title
Etiology of early age onset substance use disorder: A maturational perspective.
- Authors
TARTER, RALPH; VANYUKOV, MICHAEL; GIANCOLA, PETER; DAWES, MICHAEL; BLACKSON, TIMOTHY; MEZZICH, ADA; CLARK, DUNCAN B.
- Abstract
The etiology of early age onset substance use disorder (SUD), an Axis I psychiatric illness, is examined from the perspective of the multifactorial model of complex disorders. Beginning at conception, genetic and environment interactions produce a sequence of biobehavioral phenotypes during development which bias the ontogenetic pathway toward SUD. One pathway to SUD is theorized to emanate from a deviation in somatic and neurological maturation, which, in the context of adverse environments, predisposes to affective and behavioral dysregulation as the cardinal SUD liability-contributing phenotype. Dysregulation progresses via epigenesis from difficult temperament in infancy to conduct problems in childhood to substance use by early adolescence and to severe SUD by young adulthood.
- Publication
Development & Psychopathology, 1999, Vol 11, Issue 4, p657
- ISSN
0954-5794
- Publication type
Article
- DOI
10.1017/s0954579499002266