We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antenatal immunoglobulin for prevention of neonatal hemochromatosis.
- Authors
Okada, Noriki; Ihara, Yoshiyuki; Urahashi, Taizen; Sanada, Yukihiro; Yamada, Naoya; Hirata, Yuta; Tashiro, Masahisa; Katano, Takumi; Ushijima, Kentaro; Otomo, Shinya; Takahashi, Hironori; Matsubara, Shigeki; Mizuta, Koichi
- Abstract
Neonatal hemochromatosis ( NH) is a rare disease with a poor prognosis, particularly prior to 2008. Antenatal maternal high-dose immunoglobulin (Ig) is effective in preventing NH recurrence, but the adverse effects of this treatment have not been documented as yet. Here, we report on a patient who underwent high-dose Ig treatment to prevent NH recurrence. The patient was a 31-year-old pregnant Japanese woman. Her first child died of NH after receiving living donor liver transplantation. The patient received high-dose Ig treatment to prevent recurrence of NH from gestational weeks 16 to 35. During the treatment, platelet count gradually decreased, and cesarean section was required at 35 gestational weeks. The child did not develop liver failure. High-dose Ig prevented the recurrence of NH. Caution should be exercised due to possible adverse effects of this treatment.
- Subjects
JAPAN; THERAPEUTIC use of immunoglobulins; HEMOCHROMATOSIS; INBORN errors of metabolism; IMMUNOGLOBULINS; TREATMENT effectiveness; PREGNANCY; PREVENTION
- Publication
Pediatrics International, 2016, Vol 58, Issue 10, p1059
- ISSN
1328-8067
- Publication type
Article
- DOI
10.1111/ped.13028