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- Title
Bone neo-formation and mineral degradation of 4Bone.<sup>®</sup> Part II: histological and histomorphometric analysis in critical size defects in rabbits.
- Authors
Calvo‐Guirado, José Luis; Maté‐Sánchez, Jose E.; Delgado‐Ruiz, Rafael A.; Romanos, Georgios E.; De Aza‐Moya, Piedad; Velázquez, Pablo
- Abstract
Objective To carry out the histological and histomorphometric plus radiological analysis of biphasic ceramic. Materials and method In this study, porous HA/β TCP (4Bone®) ceramic material was tested for the bone repairing capacity and osteoinductive potential in a New Zealand rabbit model. The ratio of the ceramic′s components HA/β TCP was 60/40 (in wt%). Results The 4Bone® showed significantly more bone formation in the pores and in the periphery of the graft than the control group. Histomorphometric analysis revealed that the ceramic material (66.43% ± 0.29) produced higher values of bone-to-implant contact ( BIC) percentages (higher quality, closer contact); moreover, defect closure was significative higher in relation with control group (64.15% ± 3.52). Conclusions 4Bone® is a biocompatible, partially resorbable and osteoconductive grafting material. Biphasic graft material of HA/β TCP with a porosity of 95% without loading favors new bone formation.
- Subjects
BONE growth; TOOTH demineralization; HISTOMORPHOMETRY; HISTOLOGY; LABORATORY rabbits; CONTROL groups; BONE substitutes; TRAUMATIC bone defects
- Publication
Clinical Oral Implants Research, 2015, Vol 26, Issue 12, p1402
- ISSN
0905-7161
- Publication type
Article
- DOI
10.1111/clr.12465