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- Title
Is the Salk principle still viable for the design of an effective HIV vaccine?
- Authors
Lundgren, J. D.
- Abstract
Enormous resources are currently being expended on the development of an effective HIV vaccine, for good and obvious reasons. One of the earlier vaccine approaches was to apply the principles used by Jonas Salk when his group developed the polio vaccine in the 1950s, namely to use whole but inactivated virus. Studies on HIV-1 immunogen have shown several important lessons regarding the immune response to HIV infection and the ability to manipulate that immune response in a clinically effective manner. It is possible to increase in vitro lymphocyte proliferative responses to the p24 antigen. It has been postulated by many groups that this in vitro measurement is an important reflection of the ability of the host to suppress HIV replication.
- Subjects
HIV infections; SALK, Jonas, 1914-1995; HIV-positive persons; AIDS; HIV antibodies; HUMAN immunogenetics
- Publication
HIV Medicine, 2004, Vol 5, Issue 5, p315
- ISSN
1464-2662
- Publication type
Article
- DOI
10.1111/j.1468-1293.2004.00229.x