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- Title
The Impact of the Ca 2+ -Independent Phospholipase A 2 β (iPLA 2 β) on Immune Cells.
- Authors
White, Tayleur D.; Almutairi, Abdulaziz; Tusing, Ying Gai; Lei, Xiaoyong; Ramanadham, Sasanka
- Abstract
The Ca2+-independent phospholipase A2β (iPLA2β) is a member of the PLA2 family that has been proposed to have roles in multiple biological processes including membrane remodeling, cell proliferation, bone formation, male fertility, cell death, and signaling. Such involvement has led to the identification of iPLA2β activation in several diseases such as cancer, cardiovascular abnormalities, glaucoma, periodontitis, neurological disorders, diabetes, and other metabolic disorders. More recently, there has been heightened interest in the role that iPLA2β plays in promoting inflammation. Recognizing the potential contribution of iPLA2β in the development of autoimmune diseases, we review this issue in the context of an iPLA2β link with macrophages and T-cells.
- Subjects
BONE growth; CELL death; NEUROLOGICAL disorders; METABOLIC disorders; AUTOIMMUNE diseases
- Publication
Biomolecules (2218-273X), 2021, Vol 11, Issue 4, p577
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom11040577