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- Title
Facile Preparation of Fe3O4/C Nanocomposite and Its Application for Cost-Effective and Sensitive Detection of Tryptophan.
- Authors
Liu, Jun; Dong, Shuai; He, Quanguo; Yang, Suchun; Xie, Mei; Deng, Peihong; Xia, Yonghui; Li, Guangli
- Abstract
In this study, we reported facile synthesis of Fe3O4/C composite and its application for the cost-effective and sensitive determination of tryptophan (Trp) in human serum samples. Fe3O4/C composites were prepared by a simple one-pot hydrothermal method followed by a mild calcination procedure, using FeCl3∙6H2O as Fe3O4 precursor, and glucose as reducing agent and carbon source simultaneously. The Fe3O4/C composite modified glassy carbon electrode (Fe3O4/C/GCE) was prepared by drop-casting method. The microstructure and morphology of Fe3O4/C composite was characterized by powder X-ray diffraction (XRD) and scanning electron microscopy (SEM), respectively. Due to large specific surface area and synergistic effect from Fe3O4 nanoparticles and carbon coating, Fe3O4/C composite showed excellent electrocatalytic activity toward the oxidation of Trp. As a result, the proposed Fe3O4/C/GCE displayed superior analytical performances toward Trp determination, with two wide detection ranges (1.0–80 μM and 80–800 μM) and a low detection limit (0.26 μM, S/N = 3). Moreover, successful detection of Trp in human serum samples further validate the practicability of the proposed sensor.
- Subjects
TRYPTOPHAN; CARBON electrodes; X-ray powder diffraction; SCANNING electron microscopy; DETECTION limit; REDUCING agents
- Publication
Biomolecules (2218-273X), 2019, Vol 9, Issue 6, p245
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom9060245