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- Title
Development and Validation of a Predictive Tool for Postpartum Hemorrhage after Vaginal Delivery: A Prospective Cohort Study.
- Authors
Bihan, Line; Nowak, Emmanuel; Anouilh, François; Tremouilhac, Christophe; Merviel, Philippe; Tromeur, Cécile; Robin, Sara; Drugmanne, Guillaume; Le Roux, Liana; Couturaud, Francis; Le Moigne, Emmanuelle; Abgrall, Jean-François; Pan-Petesch, Brigitte; de Moreuil, Claire
- Abstract
Simple Summary: Postpartum hemorrhage is a major health issue, affecting pregnant women world-wide. In this study, we derived and validated a robust predictive model identifying women at risk of postpartum hemorrhage after vaginal delivery. We first used clinical and biological data from a prospective cohort of 2742 pregnant women with vaginal delivery at Brest University Hospital (France) between April 2013 and May 2015. We determined then the parameters independently associated with an increased risk of PPH (pre-eclampsia, antepartum bleeding, multiple pregnancy, labor duration ≥ 8 h, macrosomia, episiotomy, platelet count < 150 Giga/L and aPTT ratio ≥ 1.1). Afterwards, we built a predictive score with these parameters, ranging from 0 to 10. Finally, we validated this score on an independent prospective cohort of 3061 vaginal deliveries. This score has the potential to improve the care of pregnant women and to take preventive actions on them. Postpartum hemorrhage (PPH) is one of the leading causes of maternal morbidity worldwide. This study aimed to develop and validate a predictive model for PPH after vaginal deliveries, based on routinely available clinical and biological data. The derivation monocentric cohort included pregnant women with vaginal delivery at Brest University Hospital (France) between April 2013 and May 2015. Immediate PPH was defined as a blood loss of ≥500 mL in the first 24 h after delivery and measured with a graduated collector bag. A logistic model, using a combination of multiple imputation and variable selection with bootstrap, was used to construct a predictive model and a score for PPH. An external validation was performed on a prospective cohort of women who delivered between 2015 and 2019 at Brest University Hospital. Among 2742 deliveries, PPH occurred in 141 (5.1%) women. Eight factors were independently associated with PPH: pre-eclampsia (aOR 6.25, 95% CI 2.35–16.65), antepartum bleeding (aOR 2.36, 95% CI 1.43–3.91), multiple pregnancy (aOR 3.24, 95% CI 1.52–6.92), labor duration ≥ 8 h (aOR 1.81, 95% CI 1.20–2.73), macrosomia (aOR 2.33, 95% CI 1.36–4.00), episiotomy (aOR 2.02, 95% CI 1.40–2.93), platelet count < 150 Giga/L (aOR 2.59, 95% CI 1.47–4.55) and aPTT ratio ≥ 1.1 (aOR 2.01, 95% CI 1.25–3.23). The derived predictive score, ranging from 0 to 10 (woman at risk if score ≥ 1), demonstrated a good discriminant power (AUROC 0.69; 95% CI 0.65–0.74) and calibration. The external validation cohort was composed of 3061 vaginal deliveries. The predictive score on this independent cohort showed an acceptable ability to discriminate (AUROC 0.66; 95% CI 0.62–0.70). We derived and validated a robust predictive model identifying women at risk for PPH using in-depth statistical methodology. This score has the potential to improve the care of pregnant women and to take preventive actions on them.
- Subjects
POSTPARTUM hemorrhage; DELIVERY (Obstetrics); MULTIPLE pregnancy; LONGITUDINAL method; PREGNANT women; COHORT analysis
- Publication
Biology (2079-7737), 2023, Vol 12, Issue 1, p54
- ISSN
2079-7737
- Publication type
Article
- DOI
10.3390/biology12010054