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- Title
CRISPR-Cas system: a potential alternative tool to cope antibiotic resistance.
- Authors
Aslam, Bilal; Rasool, Maria; Idris, Adi; Muzammil, Saima; Alvi, Roman Farooq; Khurshid, Mohsin; Rasool, Muhammad Hidayat; Zhang, Derong; Ma, Zhongren; Baloch, Zulqarnain
- Abstract
Antibiotic exposure leads to massive selective pressures that initiate the emergence and spread of antibiotic resistance in commensal and pathogenic bacteria. The slow process of developing new antibiotics makes this approach counterintuitive for combatting the rapid emergence of new antibiotic resistant pathogens. Therefore, alternative approaches such as, the development of nucleic acid-based anti-bacterial treatments, anti-bacterial peptides, bacteriocins, anti-virulence compounds and bacteriophage therapies should be exploited to cope infections caused by resistant superbugs. In this editorial, we discuss how the newly popular CRISPR-Cas system has been applied to combat antibiotic resistance.
- Subjects
DRUG resistance in bacteria; MULTIDRUG resistance in bacteria; PATHOGENIC bacteria; BACTERIOCINS; BACTERIOPHAGES
- Publication
Antimicrobial Resistance & Infection Control, 2020, Vol 9, Issue 1, p1
- ISSN
2047-2994
- Publication type
Letter
- DOI
10.1186/s13756-020-00795-6