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- Title
Endothelin receptor antagonists in diabetic and non-diabetic chronic kidney disease.
- Authors
Ivković, Vanja; Bruchfeld, Annette
- Abstract
Chronic kidney disease (CKD) is one of the major causes of morbidity and mortality, affecting >800 million persons globally. While we still lack efficient, targeted therapies addressing the major underlying pathophysiologic processes in CKD, findings of several recent trials have brought about a shifting landscape of promising therapies. The endothelin system has been implicated in the pathophysiology of CKD and endothelin receptor antagonists are one class of drugs for which we have increasing evidence of efficacy in these patients. In this review we summarize the most recent findings on the safety and efficacy of endothelin receptor antagonists in diabetic and non-diabetic CKD, future directions of research and upcoming treatments.
- Subjects
ENDOTHELIN receptors; CHRONIC kidney failure
- Publication
Clinical Kidney Journal, 2024, Vol 17, Issue 4, p1
- ISSN
2048-8505
- Publication type
Article
- DOI
10.1093/ckj/sfae072