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- Title
ANÁLISE HISTOLÓGICA DO ESTÔMAGO DA PROLE DE RATAS WISTAR SUBMETIDAS AO CONSUMO CRÔNICO DE ÁLCOOL DURANTE A PRENHEZ.
- Authors
Gonçalves Ferreira, Jivaldo; de Sousa Coelho, Ilka Dayane Duarte; Lapa Neto3, Clovis José Cavalcanti; de Aguiar Júnior, Francisco Carlos Amanajás; Wanderley Teixeira, Valéria; Coelho Teixeira, Álvaro Aguiar
- Abstract
Consumption of alcoholic beverages during pregnancy is a significant public health issue since it can damage the organogenesis of several organs, including the stomach; however, few studies evaluate the effect of prenatal exposure to alcohol in this organ. The objective of this study was to analyze the histology of the stomach of offspring of rats submitted to chronic alcohol consumption during pregnancy. Ten pregnant rats were divided into two groups: Control - rats receiving distilled water throughout the gestation period, and Alcohol - rats receiving absolute ethyl alcohol (3g/kg/day) throughout the gestation period. After birth, 12 newborn rats (6 males and 6 females) from each group were anesthetized and their stomachs were collected. Subsequently, the organs were fixed and processed following the routine histological technique. The mucosa, muscle and total stomach were submitted to histomorphometric analyses. It was observed that the male and female offspring exposed to ethanol had a decrease in the epithelium area. However, males also showed a significant reduction in the number of epithelial cells. There was also a reduction in the layer's thickness mucosa, muscle and total stomach wall of the female offspring from the alcohol group. Additionally, the muscular layer presented a significant increase in its thickness in the group of male neonates exposed to ethanol. It can be concluded that prenatal exposure to alcohol causes harmful effects on neonates' stomachs; however, future studies are necessary to better elucidate the mechanisms involved in the pathogenesis and possible consequences for the animals in adulthood.
- Publication
Arquivos de Ciências da Saúde da UNIPAR, 2019, Vol 23, Issue 2, p119
- ISSN
1415-076X
- Publication type
Article
- DOI
10.25110/arqsaude.v23i2.2019.6999