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- Title
Long-term results of children with acute myeloid leukemia: a report of three consecutive Phase III trials by the Children's Cancer Group: CCG 251, CCG 213 and CCG 2891.
- Authors
Smith, F.O.; Alonzo, T.A.; Gerbing, R.B.; Woods, W.G.; Arceci, R.J.
- Abstract
The Children's Cancer Group (CCG) conducted three Phase III prospective clinical trials for children with de novo acute myeloid leukemia between the years 1979 and 1995. A total of 1903 eligible children ages birth to 21 years of age were enrolled on CCG 251 (n=485), CCG 213 (n=532) and CCG 2891 (n=886). Follow-up is ongoing, with medians of 7.9, 10.9 and 8.6 years, respectively. These three clinical trials developed dose- and time-intensive induction regimens based upon high-dose cytarabine and daunomycin and randomly assigned patients to allogeneic bone marrow transplantation in first remission if an HLA-matched related donor was identified. Despite dose- and time-intensive induction regimens, remission induction rates remained relatively stable at 77–78%. However, overall survival, event-free survival and disease-free survival (DFS) increased for patients receiving intensive-timing induction therapy in comparison to patients who received standard-timing induction, regardless of the type of postremission therapy. Outcomes were best for patients receiving intensive-timing induction followed by matched related donor allogeneic transplantation with DFS of 65±9% at 6 years. These three clinical trials have established a strong foundation for the development of future studies focusing on further risk group stratification and the development of novel, molecularly-targeted therapies.Leukemia (2005) 19, 2054–2062. doi:10.1038/sj.leu.2403925; published online 1 September 2005
- Subjects
ACUTE myeloid leukemia in children; ACUTE myeloid leukemia; LEUKEMIA in children; CHILDHOOD cancer; BONE marrow transplantation; LEUKEMIA immunology; TUMORS in children; PEDIATRIC hematology; MEDICAL research
- Publication
Leukemia (08876924), 2005, Vol 19, Issue 12, p2054
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/sj.leu.2403925