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- Title
Pharmacologically regulated gene expression in the retina following transduction with viral vectors.
- Authors
Dejneka, N S; Auricchio, A; Maguire, A M; Ye, X; Gao, G-P; Wilson, J M; Bennett, J
- Abstract
The availability of inducible expression systems makes regulatable control of therapeutic proteins an attainable goal in gene therapy. We delivered tetracycline-inducible transgenes to the subretinal space using recombinant adenoviruses. Upon administration of doxycycline, we demonstrated reversible expression of green fluorescent protein in the retinal pigment epithelium as weft as modulation of human growth hormone produced in the retina and secreted in the blood stream. This mode of delivery and regulation offers a unique way to evaluate gene function in the eye and represents a novel method for introducing therapeutic proteins into the retina.
- Subjects
GENE therapy; TRANSGENES; RECOMBINANT viruses
- Publication
Gene Therapy, 2001, Vol 8, Issue 6, p442
- ISSN
0969-7128
- Publication type
Article
- DOI
10.1038/sj.gt.3301413