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- Title
VALIDATED RP-HPLC METHOD FOR THE ESTIMATION OF VORTIOXETINE IN BULK AND IN TABLETS.
- Authors
Sulthana, Rubeena; Rubeena, K. Rajeswar; Vasanthi, R.; Raja, M. Alagar; Rao, K .N. V.
- Abstract
A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Vortioxetine in its pure form as well as in tablet dosage form. Chromatography was carried out on ODS C18 (4.6 × 250 mm, 5μm) column using Acetonitrile (100% v/v) as the mobile phase at a flow rate of 1.0 mL/min, the detection was carried out at 274nm. The retention time of the Vortioxetine was 2.252 ±0.02min. The method produce linear responses in the concentration range of 10-50μg/ml of Vortioxetine. The method precision for the determination of assay was below 2.0 %RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.
- Subjects
REVERSE phase liquid chromatography; DRUG tablets; PHARMACOLOGY; INTERFERON gamma release tests; PLANT embryology
- Publication
Pharma Science Monitor, 2017, Vol 8, Issue 2, p611
- ISSN
0976-9242
- Publication type
Article