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- Title
IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle.
- Authors
Tliba, Omar; Deshpande, Deepak; Hang Chen; Besien, Christopher Van; Kannan, Mathur; Panettieri Jr, Reynold A.; Amrani, Yassine; Chen, Hang; Van Besien, Christopher; Panettieri, Reynold A Jr
- Abstract
Growing evidence suggests that interleukin (1L)-13. a Th2-type cylokine, plays a critical role in the-development of bronchial hyper -responsiveness (BHR). an essentiaI feature of asthma, although the underlying mechanisms remain unknown. In the present study. we investigated whether 1L-13 directly affects airway smooth muscle (ASM) function. In murine tracheal rings. IL-13 (100ngml[sub-1], 24h) significantly increased both the carbachol- and KCI-induced maximal force generation without affecting ASM sensitivity. In cultured human ASM cells. IL-13 (50 ng ml[sub-1], 24h) also augmented cytosolic calcium levels to bradykinin. histamine and carbachol by 60.35 and 26% respectively. The present study demonstrates that IL -13 may promote BHR by directly modulating ASM contractility. an effect that may he due to enhanced G protein-coupled receptor (GPCR)-associated calcium signaling.
- Subjects
ASTHMA; SMOOTH muscle; MUSCLE contraction; CYTOKINES; CALCIUM metabolism; G proteins; HISTAMINE
- Publication
British Journal of Pharmacology, 2003, Vol 140, Issue 7, p1159
- ISSN
0007-1188
- Publication type
journal article
- DOI
10.1038/sj.bjp.0705558