We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation.
- Authors
Hansen, Signe Schmidt Kjølner; Krautz, Robert; Rago, Daria; Havelund, Jesper; Stigliani, Arnaud; Færgeman, Nils J.; Prézelin, Audrey; Rivière, Julie; Couturier-Tarrade, Anne; Akimov, Vyacheslav; Blagoev, Blagoy; Elfving, Betina; Neess, Ditte; Vogel, Ulla; Khodosevich, Konstantin; Hougaard, Karin Sørig; Sandelin, Albin
- Abstract
The fetal development of organs and functions is vulnerable to perturbation by maternal inflammation which may increase susceptibility to disorders after birth. Because it is not well understood how the placenta and fetus respond to acute lung- inflammation, we characterize the response to maternal pulmonary lipopolysaccharide exposure across 24 h in maternal and fetal organs using multi-omics, imaging and integrative analyses. Unlike maternal organs, which mount strong inflammatory immune responses, the placenta upregulates immuno-modulatory genes, in particular the IL-6 signaling suppressor Socs3. Similarly, we observe no immune response in the fetal liver, which instead displays metabolic changes, including increases in lipids containing docosahexaenoic acid, crucial for fetal brain development. The maternal liver and plasma display similar metabolic alterations, potentially increasing bioavailability of docosahexaenoic acid for the mother and fetus. Thus, our integrated temporal analysis shows that systemic inflammation in the mother leads to a metabolic perturbation in the fetus. Maternal immune activation during pregnancy can negatively impact the developing fetus. Here, applying multi-omics (RNA-seq, phosphoproteomics and lipidomics) and imaging, the authors show that while maternal immune activation induces strong innate response in maternal organs it does not extend through the placenta but leads to fetal metabolic changes.
- Subjects
MATERNAL immune activation; FETUS; PLACENTA; FETAL development; FETAL brain; MORPHOGENESIS; PLACENTA praevia
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-48492-x