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- Title
Distinct amyloid-dependent patterns of nigra dopamine depletion in Lewy body diseases.
- Authors
Kyoungwon Baik; Jungho Cha; Mincheol Park; Younggun Lee; Seok Jong Chung; Han Soo Yoo; Sohn, Young H.; Phil Hyu Lee
- Abstract
Introduction: Concomitant amyloid pathology is not uncommon and contributes to the clinical characteristics of Lewy body disease (LBD). We investigated the effect of amyloid on striatal 18F-FP-CIT uptake patterns in LBD, including Parkinson's disease (PD) and dementia with Lewy bodies. Methods: We enrolled 125 patients with LBD who underwent 18F-florbetaben positron emission tomography (PET) and 18F-FP-CIT PET. Patients were divided into amyloid-positive and amyloid-negative groups. We investigated the effect of amyloid on striatal dopamine transporter (DAT) availability, depending on the type of LBD, using general linear models with interaction analysis after controlling for age, sex, education, deep white matter hyperintensity (WMH), periventricular WMH, and cognitive status. Results: There was a significant interaction effect between the disease group and the presence of amyloid on DAT availability in the anterior putamen, posterior putamen, caudate, and ventral striatum. In the presence of amyloid, only the PD group exhibited decreased DAT availability in the anterior and posterior putamen. In both groups, the presence of amyloid was not associated with DAT availability in the caudate and ventral striatum. The presence of amyloid was not directly related to the worse parkinsonian motor symptoms in both groups. However, there was a significant indirect effect of amyloid on parkinsonian motor symptoms, which was mediated by anterior and posterior putaminal DAT availability in the PD group alone. Discussion: This study demonstrates different amyloid-dependent or amyloid- independent 18F-FP-CIT PET patterns in patients with LBD, suggesting distinctive interactions between α-synuclein and amyloid pathology based on the type of LBD.
- Subjects
SOUTH Korea; DOPAMINE analysis; AMYLOID; LEWY body dementia; NERVE tissue proteins; ACADEMIC medical centers; BASAL ganglia; RADIOISOTOPES; COMPARATIVE studies; NEUROPSYCHOLOGICAL tests; WHITE matter (Nerve tissue); T-test (Statistics); PARKINSON'S disease; MEMBRANE transport proteins; POSITRON emission tomography; RESEARCH funding; CHI-squared test; FACTOR analysis; SYNUCLEINS; DATA analysis software; SYMPTOMS
- Publication
Frontiers in Aging Neuroscience, 2023, p01
- ISSN
1663-4365
- Publication type
Article
- DOI
10.3389/fnagi.2023.1196602