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- Title
The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people.
- Authors
Ramezani-Jolfaie, Nahid; Aghaei, Shiva; Yazd, Ehsan Farashahi; Moradi, Ali; Mozaffari-Khosravi, Hassan; Amiri, Mojgan; Raeisi-Dehkordi, Hamidreza; Moghtaderi, Fatemeh; Zimorovat, Alireza; Yasini Ardakani, Seyed Ali; Salehi-Abargouei, Amin
- Abstract
Introduction: Cholesteryl ester transfer protein (CETP) is a key regulating enzyme in the lipid metabolism pathway, and its gene polymorphism may be a candidate for modulating the metabolic responses to dietary intervention. We thus examined whether the effects of the CETP TaqIB polymorphism on metabolic profiles were modified by dietary plant oils. Methods: This is a retrospective analysis of data collected during a randomized triple-blind crossover trial. A total of 95 patients with type 2 diabetes and 73 non-diabetes individuals completed a 9-week of the intake of sesame, canola and sesame-canola oils. Blood samples were collected at the beginning and at the end of each intervention period for biochemical analysis. Genotyping was done using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: In diabetes patients, B1B1 homozygotes of the CETP TaqIB polymorphism compared with B2 carriers (B1B2 + B2B2) had significantly lower diastolic blood pressure, apoB and apoB: apoA-1, and higher Lp(a) after the intake of sesame-canola oil, as well as lower insulin and HOMA-IR after the intake of sesame oil. There was also a significant effect of genotype on adjusted changes of apoB, apoB: apoA-1, insulin, HOMA-IR and QUICKI. A significant genotype-dietary oils combined effects were observed for diastolic blood pressure, and LDL: HDL, TC: HDL and TG: HDL ratios in diabetes patients. No independent or combined effects of dietary oils and genotypes on outcomes were found in healthy people. Conclusion: There was a modulatory effect of the CETP TaqIB polymorphism on some metabolic traits in response to plant oils in patients with diabetes. Taken together, the intake of sesame-canola and canola oils showed more favorable effects in diabetes patients with B1B1 genotype. Future investigations are needed to confirm these results.
- Subjects
LIPID metabolism; CANOLA oil; DRINKING (Physiology); GENETIC polymorphisms; GLYCOPROTEINS; METABOLIC disorders; POLYMERASE chain reaction; SESAME oil; TREATMENT effectiveness; RETROSPECTIVE studies; GENOTYPES
- Publication
Journal of Cardiovascular & Thoracic Research, 2020, Vol 12, Issue 3, p185
- ISSN
2008-5117
- Publication type
Article
- DOI
10.34172/jcvtr.2020.32