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- Title
New insights on atherosclerosis: A cross-talk between endocannabinoid systems with gut microbiota.
- Authors
Moludi, Jalal; Alizadeh, Mohammad; Lotfi Yagin, Ned; Pasdar, Yahiya; Nachvak, Seyed Mostafa; Abdollahzad, Hadi; Sadeghpour Tabaei, Ali
- Abstract
The incidence of atherosclerosis is increasing rapidly all over the world. Inflammatory processes have outstanding role in coronary artery disease (CAD) etiology and other atherosclerosis manifestations. Recently attentions have been increased about gut microbiota in many fields of medicine especially in inflammatory diseases like atherosclerosis. Ineffectiveness in gut barrier functions and subsequent metabolic endotoxemia (caused by rise in plasma lipopolysaccharide levels) is associated with low-grade chronic inflammation i.e. a recognized feature of atherosclerosis. Furthermore, the role of trimethylamine-N-oxide (TMAO), a gut bacterial metabolite has been suggested in atherosclerosis development. On the other hand, the effectiveness of gut microbiota modulation that results in TMAO reduction has been investigated. Moreover, considerable evidence supports a role for the endocannabinoid system (ECS) in atherosclerosis pathology which affects gut microbiota, but their effects on atherosclerosis are controversial. Therefore, we presented some evidence about the relationship between gut microbiota and ECS in atherosclerosis. We also presented evidences that gut microbiota modulation by pre/probiotics can have significant influence on the ECS.
- Subjects
ATHEROSCLEROSIS; CORONARY disease; INFLAMMATION; NEURAL transmission; GUT microbiome; PROBIOTICS; ENDOTOXEMIA; PREBIOTICS; LIPOPOLYSACCHARIDES
- Publication
Journal of Cardiovascular & Thoracic Research, 2018, Vol 10, Issue 3, p129
- ISSN
2008-5117
- Publication type
Article
- DOI
10.15171/jcvtr.2018.21