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- Title
Metastatic small cell cancer of the liver.
- Authors
Tsvetkova, Elena; Asmis, Timothy; Mai, Kien-T
- Abstract
Small cell cancer of extrapulmonary origin (EPSCC) is a rare disease, with an incidence of 0.1% to 0.4%. There is limited data on management of EPSCC due to the rarity of this condition. We report a case of metastatic small cell liver cancer in a 56-year-old woman. The patient presented with obstructive jaundice and was found to have a bilirubin of 292 μmol/L. Computed tomography (CT) scan detected a large liver mass of 7.8 cm encasing a common hepatic artery with intrahepatic biliary dilatation, and a 0.8 cm left hilar lymph node. Despite drainage, her bilirubin remained in the range of 100 μmol/L. After discussing possible side effects and complications, the patient was started on palliative chemotherapy with cisplatin (80% of ideal dose) and etoposide (75% dose reduction). At the end of the sixth cycle, she showed excellent response without significant toxicides. The liver lesion decreased in size to 4.1 cm, with normalized bilirubin; the left hilar lymph node remained stable on the last CT scan. With this case report, we emphasize the consideration of treatment in patients with high bilirubin level, after discussion of possible complications and further investigation.
- Subjects
SMALL cell carcinoma; LUNG diseases; BILIRUBIN; CANCER chemotherapy; COMPUTED tomography
- Publication
Oncology Exchange, 2016, Vol 15, Issue 2, p17
- ISSN
1705-2394
- Publication type
Case Study