We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of antiretroviral resistance and virological failure on HIV-1 informational entropy.
- Authors
Lima, Elidamar Nunes de Carvalho; Piqueira, José Roberto Castilho; Camargo, Michelle; Galinskas, Juliana; Sucupira, Maria Cecilia; Diaz, Ricardo Sobhie
- Abstract
<bold>Objectives: </bold>The present study investigated the relationship between genomic variability and resistance of HIV-1 sequences in protease (PR) and reverse transcriptase (RT) regions of the pol gene. In addition, we analysed the resistance among 651 individuals presenting antiretroviral virological failure, from 2009 to 2011, in the state of São Paulo, Brazil.<bold>Methods: </bold>The genomic variability was quantified by using informational entropy methods and the relationship between resistance and replicative fitness, as inferred by the residual viral load and CD4+ T cell count.<bold>Results: </bold>The number of antiretroviral schemes is related to the number of resistance mutations in the HIV-1 PR (α = 0.2511, P = 0.0003, R2 = 0.8672) and the RT (α = 0.7892, P = 0.0001, R2 = 0.9141). Increased informational entropy rate is related to lower levels of HIV-1 viral loads (α = -0.0121, P = 0.0471, R2 = 0.7923), lower levels of CD4+ T cell counts (α = -0.0120, P = 0.0335, R2 = 0.8221) and a higher number of antiretroviral resistance-related mutations.<bold>Conclusions: </bold>Less organized HIV genomes as inferred by higher levels of informational entropy relate to less competent host immune systems, lower levels of HIV replication and HIV genetic evolution as a consequence of antiretroviral resistance.
- Subjects
BRAZIL; HIV infection genetics; ANTIRETROVIRAL agents; DNA polymerases; DRUG resistance in microorganisms; HIV; HIV infections; GENETIC mutation; PROTEOLYTIC enzymes; T cells; VIRAL load; TREATMENT effectiveness; CD4 lymphocyte count; SEQUENCE analysis
- Publication
Journal of Deaf Studies & Deaf Education, 2018, Vol 23, Issue 2, p1054
- ISSN
1081-4159
- Publication type
journal article
- DOI
10.1093/jac/dkx508