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- Title
A Review on the Management of Peripheral Neuropathic Pain Following Breast Cancer.
- Authors
Avila, Francisco; Torres-Guzman, Ricardo; Maita, Karla; Garcia, John P; De Sario, Gioacchino D; Borna, Sahar; Ho, Olivia A; Forte, Antonio J
- Abstract
Postmastectomy pain syndrome (PMPS) is a common and debilitating form of postsurgical pain with neuropathic characteristics, presenting as burning, stabbing, or pulling sensations after mastectomy, lumpectomy, or other breast procedures. With a prevalence of 31%, the risk factors for PMPS include younger age, psychosocial factors, radiotherapy, axillary lymph node dissection, and a history of chronic pain. This review evaluates the pharmacological and surgical options for managing PMPS. Pharmacological treatment options include antidepressants, gabapentinoids, levetiracetam, capsaicin, and topical lidocaine. Procedural and surgical options include fat grafting, nerve blocks, radiofrequency ablation, peripheral nerve surgery, serratus plane block, and botulinum toxin injections. Despite the variety of therapeutic options available for patients, further randomized trials are required to conclude whether these treatments reduce the intensity of neuropathic pain in patients with PMPS. In particular, comparative studies and the inclusion of patients across a range of pain intensities will be essential to developing a treatment algorithm for PMPS. In conclusion, current management for these patients should be tailored to their individual requirements.
- Subjects
AXILLARY lymph node dissection; NERVE block; NEURALGIA; NERVE grafting; ATRIAL flutter; POSTOPERATIVE pain; BREAST cancer; NEUROSURGERY
- Publication
Breast Cancer: Targets & Therapy, 2023, Vol 15, p761
- ISSN
1179-1314
- Publication type
Article
- DOI
10.2147/BCTT.S386803