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- Title
Change of Ultrasound Estimated Bladder Weight and Bladder Wall Thickness After Treatment of Bladder Outlet Obstruction With Dutasteride.
- Authors
LEE, Ha Na; LEE, Young‐Suk; HAN, Deok Hyun; LEE, Kyu‐Sung
- Abstract
Objectives To investigate the change of bladder wall hypertrophy to relieve bladder outlet obstruction ( BOO) by treatment with 5α-reductase inhibitor. Methods Men who have BOO confirmed by urodynamic study ( BOO index ≥40) were treated with dutasteride 0.5 mg once a day for 6 months. We measured ultrasound estimated bladder weight ( UEBW), UEBW divided by body surface area ( UEBW/ BSA), and bladder wall thickness ( BWT) before and after treatment. Changes in LUTS parameters were assessed by using the International Prostate Symptom Score, uroflowmetry, residual urine volume, prostate volume, serum prostate-specific antigen ( PSA), and LUTS outcome scores ( LOS). Correlation between the change of LUTS parameters and UEBW, UEBW/ BSA, and BWT were evaluated. We assessed the changes of bladder wall hypertrophy according to the results of benefit, satisfaction, and willingness to continue ( BSW) questionnaire. Results Thirty patients completed the 6-month study. The mean UEBW was 47.10 ± 7.79 g before and 50.07 ± 5.39 g after dutasteride treatment ( P = 0.259). The mean UEBW/ BSA was 26.47 ± 4.30 g/m2 before and 28.2 ± 3.53 g/m2 after treatment ( P = 0.253), and there was no definite change in mean BWT after treatment ( P = 0.301). Most LUTS parameters including LOS significantly improved. Increased BOO index value was related to decreased BWT (ρ = 0.361, P = 0.049). There was no definite change in mean UEBW, UEBW/ BSA, and BWT according to the results of the BSW questionnaire. Conclusions There was no change in UEBW, UEBW/ BSA and BWT despite improving most clinical parameters suggesting BOO. The changes of bladder wall hypertrophy parameters still have limitations to directly reflect the relief of BOO.
- Subjects
BLADDER obstruction; PROSTATE hypertrophy; ULTRASONIC imaging; BLADDER diseases; ONTOLOGY; THERAPEUTICS
- Publication
LUTS, 2017, Vol 9, Issue 2, p67
- ISSN
1757-5664
- Publication type
Article
- DOI
10.1111/luts.12110