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- Title
Maesaquinone: A Novel Inhibitor of Plant Mitochondrial Respiratory Enzymes That React with Ubiquinone.
- Authors
Affourtit, Charles; Whitehouse, David G.; Moore, Anthony L.
- Abstract
The effect of maesaquinone, 2-(14-nonadecenyl)-3,6-dihydroxy5-methyl-1,4-benzoquinone, on plant mitochondrial respiration has been investigated. In mitochondria isolated from thermogenic Arum maculatum spadices, this compound inhibits both cytochrome and alternative pathway activities. Kinetic analyses reveal that this inhibition is the result of potent effects of maesaquinone on the alternative oxidase (ID[sub 50] <0.3θM) and complex III (ID[sub 50] <5θM). Succinate dehydrogenase and external NADH dehydrogenase are also inhibited, albeit to a lesser extent (~30% at 1 θM). These data suggest that maesaquinone specifically affects the interaction of the respective enzymes with ubiquinone.
- Subjects
PLANT mitochondria; QUINONE
- Publication
IUBMB Life, 2000, Vol 49, Issue 6, p533
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1080/15216540050167089