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- Title
Stage-dependent Increase in Expression of miR-155 and Ki-67 and Number of Tumour-associated Inflammatory Cells in Folliculotropic Mycosis Fungoides.
- Authors
ATZMONY, Lihi; MOYAL, Lilach; FEINMESSER, Meora; GOROVITZ, Batya; HIRSHBERG, Avraham; AMITAY-LAISH, Iris; PRAG-NAVEH, Hadas; BARZILAI, Aviv; HODAK, Emmilia
- Abstract
Recent studies suggest that folliculotropic mycosis fungoides (FMF), the most common variant of mycosis fungoides (MF), presents with 2 distinct clinicopathological stages: early indolent stage and more aggressive advanced/tumour stage. To further characterize these stages, miR-155 expression was studied with qRT-PCR and found to be significantly higher in biopsies of tumour-stage FMF compared with early-stage FMF and inflammatory dermatoses. There was no statistically significant difference in miR-155 expression between early-stage FMF and early-stage MF, nor between tumour-stage FMF and tumour-stage MF. Immunohistochemical analysis revealed a significantly increased number of dermal Ki-67+ proliferating lymphocytes in tumour-stage FMF, together with an increased number of CD20+ B cells and CD68+ macrophages compared with early-stage FMF. Thus, similar to classic MF, miR-155, Ki-67 tumour cell immunoreactivity, and certain tumour-infiltrating inflammatory cells are differentially expressed in early- vs tumour-stage FMF. The results of this study corroborate the notion that FMF presents with 2 distinct stages.
- Subjects
MYCOSIS fungoides; CUTANEOUS T-cell lymphoma; B cells; CELLS
- Publication
Acta Dermato-Venereologica, 2020, Vol 100, Issue 8, p1
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-3578