We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antimicrobial Property of Zingiber officinalis Extract on Streptococcus mutans.
- Authors
Yapong, Bunjird; Jitpukdeebodintra, Suwanna; Rotpenpian, Nattapon
- Abstract
Zingiber officinalis (Z. officinalis) from Apiaceae family is Ayurveda medicine in Asia. Z. officinalis is traditionally used as herbal, food, and various therapeutic purposes. This study aimed to determine the antimicrobial activity of Z. officinalis crude extract against Streptococcus mutans (S. mutans), in-vitro. Using the broth dilution method, the antibacterial activity of Z. officinalis crude extract was evaluated in terms of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Biofilm development was used to investigate the inhibitory effect of Z. officinalis extract on bacterial adhesion. The amount of water-insoluble glucan was used to determine the inhibitory effect of crude extract on glucosyltransferase (GTFs). In addition, the acidity of S. mutans pathogenesis was measured using sub-MIC level of Z. officinalis extract. The MIC and MBC of Z. officinalis crude extract against S. mutans were 31.25 and 62.50 mg/ml, respectively. Biofilm formation was inhibited at MIC and 1/2 MIC. Extracts of Z. officinalis at MIC level inhibited GTFs by more than 50%. In addition, extracts of Z. officinalis at 1/2 MIC, 1/4 MIC, and 1/8MIC showed a dose-dependent reduction in acid production. Z. officinalis extract can inhibit the virulent factor of S. mutans, which causes dental caries in humans, in vitro.
- Subjects
ASIA; GINGER; CARIOGENIC agents; STREPTOCOCCUS mutans; BACTERIAL adhesion; DENTAL caries; EXTRACTS
- Publication
Journal of International Dental & Medical Research, 2022, Vol 15, Issue 4, p1492
- ISSN
1309-100X
- Publication type
Article