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- Title
Establishment and Characterization of Rabbit Model for Alveolar Bone Regeneration.
- Authors
Thuy-Duong Thi Nguyen; My-Huong Le; Tan-Tai Tran; Tae-Sung Bae; Tung Nguyen-Thanh
- Abstract
The target of this study was to establish an animal model for reconstructing critical-sized alveolar defects, allow the experimental testing of advanced alveolar regeneration without causing any damage to the health of the animal. Alveolar bone defect operation was executed at the lateral side of the right central incisor to create a bony deformity after tooth extraction in New Zealand White rabbit. They were sacrificed at the fixed point of time to either harvest the skulls or perform Radiographic analysis and histological survey with Hematoxylin and Eosin staining to evaluate the bone regeneration at operative site. Clinical examination and imaging assessment was capable of presenting a critical-sized alveolar bone defect. Soft tissue started to heal gradually, no signs of inflammation and swelling at surgical site was reported and bone regeneration completed after 8 weeks. Radiographic survey displayed the increasing density contrast after surgery, replaced the C-shaped radiolucent at the surgical site. It also correspond the developement of bone in the harvested skulls, in which the amount of bone started to rise from 0-8 weeks. Histological analysis showed the step-by-step formation of different structures at surgical sites.. The bone and connective tissue completely filled the defect after 8 weeks. Our surgical procedure was capable of establishing an alveolar defect model in the central incisor region of the rabbit maxilla. It demonstrates the capability of this model as a test bed for assessing the healing capacity of soft tissues and alveolar bone regeneration.
- Subjects
ALVEOLAR process; BONE regeneration; DENTAL extraction; HEMATOXYLIN &; eosin staining; TOOTH socket; OPERATIVE surgery; SURGICAL site
- Publication
Journal of International Dental & Medical Research, 2021, Vol 14, Issue 3, p887
- ISSN
1309-100X
- Publication type
Article