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- Title
Vitamin E and C protects the liver from diclofenac‑induced histopathological changes and oxidative damage in experimental animals.
- Authors
Thirusangu, Siva; Sivakumar, Girija; Kasirajan, Sankaran Ponnusamy; Francis, Yuvaraj Maria
- Abstract
Aim: This study was done to show the changes in the liver following diclofenac treatment and to study the hepatoprotective effects of Vitamin E and C in diclofenac treated rats. Materials and Methods: Rats were divided into four groups each six rats. Group-1: Control rats (n = 6), Group-2: Rats (n = 6) treated with diclofenac at dose of 50 mg/kg IM for 7 days, Group-3: Rats (n = 6) treated with Vitamin C at dose of 200 mg/kg orally followed by diclofenac at 50 mg/kg IM 2 h later for 7 days, and Group 4: Rats (n = 6) treated with Vitamin E at dose of 200 IU/kg orally followed by diclofenac at 50 mg/kg IM 2 h later for 7 days. Later it was analyzed with standard biomarkers, and it was histologically interpreted. Results: the results showed that there was an rapid increase in the levels of liver function test in diclofenac treated group, which was significantly decreased after pretreatment with vitamin E than vitamin c. The liver acinus showed centriacinar necrosis of hepatocytes after 7 days of diclofenac treatment, which was prevented by administration of Vitamin E and C. Discussion: Drug-induced liver injury possesses a major clinical problem and has become a leading cause of acute liver failure and transplantation. Overstressed liver compromises its detoxification role which may expose it to a variety of diseases and disorders. Diclofenac sodium is a phenylacetic acid derivative, a widely used nonsteroidal anti-inflammatory drug (NSAID) for the treatment of inflammatory conditions such as osteoarthritis, rheumatoid arthritis, polymyositis, dermatomyositis, dental pain, spondyloarthritis, acute migraine, gout attacks, and pain management in gall and renal stones. Although the exact mechanism by with diclofenac injuries liver is not understood, some studies explain the toxicity by affecting cytochrome P 450 leading to the production of active metabolites. Conclusion: hepatoprotective effects of Vitamin E were better compared to Vitamin C following treatment with NSAID. Hence, it may be necessary to administer Vitamin E in patients treated with diclofenac.
- Subjects
VITAMIN E; POLYMYOSITIS; VITAMIN C; VITAMINS; LABORATORY animals; PHENYLACETIC acid; DISEASES; TOOTHACHE
- Publication
Drug Invention Today, 2019, Vol 12, Issue 3, p434
- ISSN
0975-7619
- Publication type
Article