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- Title
Evaluation of quercetin-loaded poly-lactide-co-glycolide acid silver nanoparticles from the ethanolic extract of Mallotus philippensis fruits.
- Authors
Velraj, Malarkodi; Shruthi, V.; Murugavel, S.; Shanmugam, R.
- Abstract
Aims and Objectives: Simple approach for the green synthesis of silver nanoparticles from the ethanolic extract of Mallotus philippensis fruits. Materials and Methods: Quercetin isolated from the fruits of M. philippensis was loaded with poly-lactide-co-glycolide acid (PLGA) by nanoprecipitation technique since nanoparticles improve solubility in aqueous phase and increase its bioavailability. Results and Discussion: About 10 mg of quercetin isolated from the ethanolic fruit extract of M. philippensis was dissolved in acetone and was added with 100 mg of PLGA with the copolymer poloxamer. The physical characterization such as ultraviolet (UV), Fourier transform-infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD) was carried out. The UV results showed the maximum absorption peak at the range of 356-436 nm. FTIR showed the presence of alcohol group, alkane group, and hydroxyl and ether groups. SEM showed the formation of silver nanoparticles with an average size of 70-339 nm. The XRD pattern revealed that the sample contains crystalline structures of silver nanoparticles. Conclusion: It proves to be an eco-friendly green novel technology, cost-effective efficient way for the synthesis of silver nanoparticles using plant extract for protecting human health and environment, leading to lesser waste and safer products.
- Subjects
QUERCETIN; LACTIDES; MALLOTUS; NANOSTRUCTURED materials synthesis; SILVER nanoparticles; DRUG bioavailability
- Publication
Drug Invention Today, 2018, Vol 10, Issue 2, p253
- ISSN
0975-7619
- Publication type
Article