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- Title
Patients' demographic and socioeconomic characteristics influence the therapeutic decision-making process in psoriasis.
- Authors
Scala, Emanuele; Megna, Matteo; Amerio, Paolo; Argenziano, Giuseppe; Babino, Graziella; Bardazzi, Federico; Bianchi, Luca; Caldarola, Giacomo; Campanati, Anna; Cannavò, Serafinella Patrizia; Chiricozzi, Andrea; Conti, Andrea; Damiani, Giovanni; Dapavo, Paolo; De Simone, Clara; Esposito, Maria; Fabbrocini, Gabriella; Fargnoli, Maria Concetta; Ferrara, Francesca; Fidanza, Rosaria
- Abstract
Background: Knowledge regarding differences in care for psoriatic patients is limited. The aim of this study was to investigate factors influencing prescription of systemic treatments for patients with psoriasis with a special focus on socioeconomic factors. Methods and findings: This was a non-interventional, cross-sectional study, conducted in 18 Italian University and/or hospital centers with psoriasis-specialized units. Questionnaires evaluating demographic and socioeconomic characteristics were administered to participants. Overall, 1880 consecutive patients affected by mild-to-severe psoriasis were recruited. Univariate and multivariable logistic regression analyses of systemic therapy prescription, with a special focus on biologics, accounting for the above mentioned characteristics were performed. Our analysis showed that all analyzed patients' characteristics were significantly associated with biological therapy compared to non-biological systemic one. Particularly, women were less likely to receive biologics than men (OR = 0.66; 95% CI, 0.57–0.77). Elderly patients (≥65 years) and subjects with a BMI ≥30 had lower odds to receive biologics respect to adults (≥35–64 years) (OR = 0.33; 95% CI, 0.25–0.40), and subjects with BMI≥25<30 (OR = 0.64; 95% CI, 0.53–0.77), respectively. Northern and Southern patients were both less likely to receive biologics than Central patients (OR = 0.75; 95% CI, 0.63–0.89, and OR = 0.56; 95% CI,0.47–0.68, respectively). Lower economic profile and never reading books were both associated with decreased odds of receiving biological therapy. Conclusions: This study shows that sex, age, comorbidities, and socioeconomic characteristics influence the prescription of systemic treatments in psoriasis, highlighting that there are still unmet needs influencing the therapeutic decision-making process that have to be addressed.
- Subjects
DEMOGRAPHIC characteristics; SOCIOECONOMIC factors; BIBLIOTHERAPY; OLDER patients; LOGISTIC regression analysis; PSORIASIS
- Publication
PLoS ONE, 2020, Vol 15, Issue 8, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0237267