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- Title
First activity and interactions in thalamus and cortex using raw single-trial EEG and MEG elicited by somatosensory stimulation.
- Authors
Karittevlis, Christodoulos; Papadopoulos, Michail; Lima, Vinicius; Orphanides, Gregoris A.; Tiwari, Shubham; Antonakakis, Marios; Lesta, Vicky Papadopoulou; Ioannides, Andreas A.
- Abstract
Introduction: One of the primary motivations for studying the human brain is to comprehend how external sensory input is processed and ultimately perceived by the brain. A good understanding of these processes can promote the identification of biomarkers for the diagnosis of various neurological disorders; it can also provide ways of evaluating therapeutic techniques. In this work, we seek the minimal requirements for identifying key stages of activity in the brain elicited by median nerve stimulation. Methods: We have used a priori knowledge and applied a simple, linear, spatial filter on the electroencephalography and magnetoencephalography signals to identify the early responses in the thalamus and cortex evoked by short electrical stimulation of the median nerve at the wrist. The spatial filter is defined first from the average EEG and MEG signals and then refined using consistency selection rules across ST. The refined spatial filter is then applied to extract the timecourses of each ST in each targeted generator. These ST timecourses are studied through clustering to quantify the ST variability. The nature of ST connectivity between thalamic and cortical generators is then studied within each identified cluster using linear and non-linear algorithms with time delays to extract linked and directional activities. A novel combination of linear and non-linear methods provides in addition discrimination of influences as excitatory or inhibitory. Results: Our method identifies two key aspects of the evoked response. Firstly, the early onset of activity in the thalamus and the somatosensory cortex, known as the P14 and P20 in EEG and the secondM20 forMEG. Secondly, good estimates are obtained for the early timecourse of activity from these two areas. The results confirm the existence of variability in ST brain activations and reveal distinct and novel patterns of connectivity in di
- Subjects
NEURAL stimulation; MEDIAN nerve; THALAMOCORTICAL system; THALAMUS; SPATIAL filters; ELECTROENCEPHALOGRAPHY; SOMATOSENSORY cortex; CARPAL tunnel syndrome; EPILEPSY
- Publication
Frontiers in Systems Neuroscience, 2024, p01
- ISSN
1662-5137
- Publication type
Article
- DOI
10.3389/fnsys.2023.1305022