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- Title
Metabolic syndrome as a risk factor for seteatofibrosis; Cross sectional study.
- Authors
Azita, Ganji; Abbas, Esmaeilzadeh; Ali, Bahari; Ladan, Goshayeshi
- Abstract
Introduction: Nonalcoholic fatty liver disease (NAFLD) is used to define a spectrum of changes in liver includes a simple steatosis, steatohepatitis, cirrhosis which can progress to cirrhosis. NAFLD had known as the hepatic manifestation of metabolic syndrome and even without cirrhosis are a risk of hepatocellular carcinoma. The aim of this study was to Evaluate the factors associated with significant liver fibrosis in nonalcoholic steatohepatitis (NASH) diagnosed by fibroscan. Methods: This cross sectional study was conducted under the supervision of Mashhad university of medical sciences. 2409 patients with non alcoholic fatty liver disease (NAFLD) enrolled in our studying and evaluate by fibroscan. Patients with underlying diseases, autoimmune hepatitis, viral hepatitis and Wilson disease were excluded from study. Metabolic syndrome was considered in patients with at least three of the 5 criteria (waist circumference, HTN, HDL, TG, FBS). Steatosis graded from normal to S3 and fibrosis from F0 to F4 by fibroscan. Results: In this study 2409 patients had fibroscan, 491 out of them had metabolic syndrome and 1918 without metabolic syndrome. Mean age was 44.72% (43.52 in MS and 49.5 in non metabolic syndrome). In patients with fatty liver, prevalance of metabolic syndrome was 58%. Mean steatosis percent had significant difference in metabolic syndrome, in compare of non metabolic syndromes (62% in compare of 71%). Patients who had more components of MS (> 3 of 5 criteria for MS) had more steatosis and more fibrosis. 70% of patients with MS had no fibrosis and 10.29% had sever fibrosis with liver stiffness more than 9.5 kps in fibroscan. Conclusion: In age more than 40 about 10 percent of patients with metabolic syndrome had sever fibrosis and 19% had significant fibrosis.
- Subjects
IRAN; CIRRHOSIS of the liver; CONFERENCES &; conventions; METABOLIC syndrome; DISEASE complications; DISEASE risk factors
- Publication
Iranian Journal of Gastroenterology & Hepatology (GOVARESH), 2017, Vol 22, Issue 3, p12
- ISSN
1560-7186
- Publication type
Article