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- Title
The role of angiotensin in the cardiovascular and renal response to salt restriction.
- Authors
Mimran, Albert; Guiod, Linda; Hollenberg, Norman K.
- Abstract
Dietary sodium restriction in rabbits resulted in a significant reduction in cardiac output: blood pressure was well maintained through an increase in total peripheral resistance. Renal blood flow, measured with tagged microspheres, and glomerular filtration rate were reduced with salt restriction. There was a larger reduction in outer cortical than inner cortical flow rates. Blockade of the renin-angiotensin system with either a competitive antagonist to angiotensin II (1-sar, 8-ala angiotensin II) or inhibition of converting enzyme (SQ 20881) reduced arterial pressure in animals on a low salt diet but not on a high salt diet. Similarly, renal blood flow increased only in animals on a low salt diet despite the fall in arterial pressure, suggesting that the vasoconstriction was mediated by the renin-angiotensin system. Despite the increase in total and outer cortical renal blood flow, however, neither an increase in the glomerular filtration rate nor natriuresis occurred in animals on a low salt diet: either the renal vascular response did not contribute to the functional effects of salt restriction or the hypotensive response overrode the renal vascular effects on sodium handling and filtration rate.
- Subjects
ANGIOTENSIN-receptor blockers; ANGIOTENSINS; OLIGOPEPTIDES; SALT; PEPTIDES; PROTEINS; BLOOD pressure; ORGANIC compounds
- Publication
Kidney International, 1974, Vol 5, Issue 5, p348
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1974.50