We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The spectrum of congenital heart diseases in down syndrome.
- Authors
Morsy, Mohamed M.; Algrigri, Osama O.; Salem, Sherif S.; Abosedera, Mostafa M.; Abutaleb, Ashraf R.; Al-Harbi, Khaled M.; Al-Mozainy, Ibrahim S.; Alnajjar, Abdulhameed A.; Habeb, Abdelhadi M.; Abo-Haded, Hany M.
- Abstract
Objectives: To to define the frequency and patterns of congenital heart disease (CHD) among children with Down syndrome (DS) in Northwest Saudi Arabia. Methods: We included children with confirmed DS referred to the regional pediatric cardiology.unit in Madinah Maternity and Children Hospital between January 2008 and December 2013. Children were identified from the unit's data-base and the charts were reviewed retrospectively. We excluded term and preterm children with patent ducts arteriosus (PDA) and persistent foramen oval spontaneously resolved during the first 4 weeks of life. Results: A total of 302 children with DS were identified (50.3% male). Of these, 177 (58.6%) had CHD. Atrioventricular septal defect (AVSD) was the most frequent lesion identified in 72/177 (40.7%) followed by mixed left to right shunt defects (14.7%) and secundum atrial septal defect (ASD) (11.8%). Ventricular septal defect was detected in 10.7% and 8.5% had PDA beyond the neonatal period. There was no gender difference in the frequency of CHD (p=0.9) and the presence of CHD was not related to the genetic cause of DS (p=0.9). Conclusion: The frequency of CHD in our DS cohort is comparable with Europe, Asia ,and other KSA regions. However its pattern appears to be different from some areas in KSA.
- Subjects
SAUDI Arabia; CONGENITAL heart disease; DOWN syndrome; PEDIATRIC cardiology; ATRIAL septal defects; COHORT analysis; RETROSPECTIVE studies
- Publication
Saudi Medical Journal, 2016, Vol 37, Issue 7, p767
- ISSN
0379-5284
- Publication type
Article
- DOI
10.15537/smj.2016.7.14536