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- Title
Efficacy of cascade plasmapheresis in comparison with conventional therapeutic plasma exchange for relapsed atypical hemolytic uremic syndrome: A case report.
- Authors
Vaidya, Ashwinkumar; Polavarapu, Isha; Prabhu, Ravindra; Mohan, Ganesh; Shastry, Shamee; Prethika, P
- Abstract
Atypical hemolytic uremic syndrome (aHUS) is a rare and life-threatening disease that is associated with high mortality and morbidity. The incidence of aHUS is about 1 or 2 cases per 1,000,000 per year. Etiology can be either familial or sporadic. The pathogenesis of aHUS involves dysregulation of the alternative complement pathway, with predisposing mutations in complement genes. aHUS has a poor prognosis and a gradual or a relapsing (30%–86%) clinical course. The disease may present at any age but is mostly seen in children and young adults. Therapeutic plasma exchange (TPE) is one of the primary modalities of treatment in aHUS. This report presents the utilization of cascade plasmapheresis and its advantages over TPE in a patient with relapsed aHUS. There was a 73% decrement in antifactor H antibody levels following cascade plasmapheresis.
- Subjects
HEMOLYTIC-uremic syndrome diagnosis; ALBUMINS; GENETIC mutation; IMMUNOGLOBULINS; PLASMA exchange (Therapeutics); DISEASES; TREATMENT effectiveness; CATASTROPHIC illness; PLASMAPHERESIS; HEMOLYTIC-uremic syndrome; RARE diseases
- Publication
Asian Journal of Transfusion Science, 2022, Vol 16, Issue 2, p283
- ISSN
0973-6247
- Publication type
Article
- DOI
10.4103/ajts.ajts_121_21