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- Title
The Relationship of Circulating Fetuin-A With Liver Histology and Biomarkers of Systemic Inflammation in Nondiabetic Subjects With Nonalcoholic Fatty Liver Disease.
- Authors
Celebi, Gurkan; Genc, Halil; Gurel, Hasan; Sertoglu, Erdim; Kara, Muammer; Tapan, Serkan; Acikel, Cengizhan; Karslioglu, Yildirim; Ercin, Cemal Nuri; Dogru, Teoman
- Abstract
Background/Aims: Fetuin-A, a glycoprotein with anti-inflammatory properties, plays an important role in counter-regulating inlammatory responses. It has also been associated with insulin resistance and metabolic syndrome. We aimed to investigate circulating concentrations of fetuin-A and its possible association with hepatic and systemic inlammation in nondiabetic subjects with nonalcoholic fatty liver disease (NAFLD). Patients and Methods: We included 105 nondiabetic male subjects with NAFLD [nonalcoholic steatohepatitis (NASH, n = 86) and simple steatosis (SS, n = 19)]. Plasma levels of fetuin-A and markers of inlammation [high-sensitive C reactive protein (hsCRP), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and adiponectin] were measured by enzyme-linked immunosorbent assay method. Insulin sensitivity was determined by homeostasis model assessment of insulin resistance (HOMA-IR) index. Results: Fetuin-A was negatively correlated with age (r = -0.27, P = 0.006), however there was no association between fetuin-A and body mass index, waist circumference (WC), glucose, insulin, HOMA-IR, lipid parameters, and inflammatory markers. In addition, no significant association was observed between fetuin-A and histological findings including liver ibrosis. Conclusion: This study demonstrated that plasma fetuin-A levels are not correlated with the hepatic histology and systemic markers of inflammation in nondiabetic subjects with NAFLD. Our data also suggested that age is significantly associated with fetuin-A in this clinically relevant condition.
- Subjects
TURKEY; ACADEMIC medical centers; BIOPSY; BLOOD testing; CHI-squared test; STATISTICAL correlation; ENZYME-linked immunosorbent assay; FATTY liver; INFLAMMATION; MULTIVARIATE analysis; REGRESSION analysis; STATISTICS; T-test (Statistics); DATA analysis; RETROSPECTIVE studies; DATA analysis software; DESCRIPTIVE statistics; MANN Whitney U Test
- Publication
Saudi Journal of Gastroenterology, 2015, Vol 21, Issue 3, p139
- ISSN
1319-3767
- Publication type
Article
- DOI
10.4103/1319-3767.157556