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- Title
Radiation-Chemical Perspective of the Radiobiology of Pulsed (High Dose-Rate) Radiation (FLASH): A Postscript.
- Authors
Wardman, Peter
- Abstract
An earlier commentary (Wardman P, Radiat Res. 2020; 194:607-617) discussed possible chemical reaction pathways that might be involved in the differential responses of tissues to high- vs. low-dose-rate irradiation, focusing on reactions between radicals, and radiolytic depletion of a chemical influencing radiosensitivity. This brief postscript updates discussion to consider recent modeling and experimental studies, and presents more detail to support the earlier suggestion that rapid depletion of nitric oxide will certainly occur after a radiation pulse of a few grays, underlining the need to include the consequences of such a change when considering FLASH effects.
- Subjects
RADIOBIOLOGY; RADIATION; RADIATION tolerance; RADICALS (Chemistry); CHEMICAL reactions
- Publication
Radiation Research, 2024, Vol 201, Issue 1, p87
- ISSN
0033-7587
- Publication type
Article
- DOI
10.1667/RADE-23-00212.1