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- Title
Association between Incidence of Prescriptions for Alzheimer's Disease and Beta-Adrenoceptor Antagonists: A Prescription Sequence Symmetry Analysis.
- Authors
Alghamdi, Ali; Bijlsma, Maarten J.; de Vos, Stijn; Schuiling-Veninga, Catharina C.M.; Bos, Jens H. J.; Hak, Eelko
- Abstract
Background: Alzheimer's disease (AD) is the most common cause of dementia, with a growing number of patients worldwide. The association between AD and treatment with drugs targeting the beta-adrenergic receptor is controversial. The aim of this study is to assess the association between the initiation of AD medication and beta-adrenoceptor antagonists (beta-blockers) in adults. Materials and Methods: We conducted a prescription sequence symmetry analysis using the University of Groningen IADB.nl prescription database. We determined the order of the first prescription for treating AD and the first prescription for beta-blockers, with the dispensing date of the first prescription for AD defined as the index date. Participants were adults over 45 years old starting any AD medication and beta-blockers within two years. We calculated adjusted sequence ratios with corresponding 95% confidence intervals. Results: We identified 510 users of both AD and beta-blockers, and 145 participants were eligible. The results were compatible with either a significant decrease in the incidence of AD after using beta-blockers (adjusted sequence ratio (aSR) = 0.52; 95% CI: 0.35–0.72) or, conversely, an increase in beta-blockers after AD medication (aSR = 1.96; 95% CI: 1.61–2.30). Conclusions: There is a relationship between the use of beta-blockers and AD medications. Further research is needed with larger populations to determine whether drug therapy for AD increases the risk of hypertension or whether beta-blockers have potential protective properties against AD development.
- Subjects
RIJKSUNIVERSITEIT te Groningen; ADRENERGIC beta blockers; ALZHEIMER'S disease; SEQUENCE analysis; BETA adrenoceptors; DRUG therapy; MEDICAL prescriptions
- Publication
Pharmaceuticals (14248247), 2023, Vol 16, Issue 12, p1694
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph16121694