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- Title
Pharmacogenetics: more than skin deep.
- Authors
McLeod, Howard L.
- Abstract
It is well known that the efficacy of certain drugs varies from individual to individual, depending in part on variation in the genes that encode drug metabolizing enzymes. Whereas ethnic and geographic differences are commonly used to classify drug response, new results show that more accurate and robust genetic clusters—identified by genotyping a modest number of neutral markers—can be inferred with no prior knowledge of ethnicity. Such an approach may eventually become a part of drug evaluation and clinical practice.
- Subjects
DRUG efficacy; DRUG metabolism; PHARMACOGENOMICS
- Publication
Nature Genetics, 2001, Vol 29, Issue 3, p247
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng1101-247