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- Title
Cortex-Wide Dynamics of Intrinsic Electrical Activities: Propagating Waves and Their Interactions.
- Authors
Yuqi Liang; Chenchen Song; Mianxin Liu; Pulin Gong; Changsong Zhou; Knöpfel, Thomas
- Abstract
Cortical circuits generate patterned activities that reflect intrinsic brain dynamics that lay the foundation for any, including stimuli-evoked, cognition and behavior. However, the spatiotemporal organization properties and principles of this intrinsic activity have only been partially elucidated because of previous poor resolution of experimental data and limited analysis methods. Here we investigated continuous wave patterns in the 0.5-4 Hz (delta band) frequency range on data from highspatiotemporal resolution optical voltage imaging of the upper cortical layers in anesthetized mice. Waves of population activities propagate in heterogeneous directions to coordinate neuronal activities between different brain regions. The complex wave patterns show characteristics of both stereotypy and variety. The location and type of wave patterns determine the dynamical evolution when different waves interact with each other. Local wave patterns of source, sink, or saddle emerge at preferred spatial locations. Specifically, "source" patterns are predominantly found in cortical regions with low multimodal hierarchy such as the primary somatosensory cortex. Our findings reveal principles that govern the spatiotemporal dynamics of spontaneous cortical activities and associate them with the structural architecture across the cortex.
- Subjects
OPTICAL resolution; SOMATOSENSORY cortex; OPTICAL images; DATA analysis
- Publication
Journal of Neuroscience, 2021, Vol 41, Issue 16, p3665
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.0623-20.2021