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- Title
Clinical Utility of Serum Interleukin-8 and Interferon-Alpha in Thyroid Diseases.
- Authors
Kobawala, Toral P.; Patel, Girish H.; Gajjar, Dhara R.; Patel, Kamini N.; Thakor, Premal B.; Parekh, Urvi B.; Patel, Kirti M.; Shukla, Shilin N.; Shah, Pankaj M.
- Abstract
Serum interleukin-8 (IL-8) and interferon-alpha (IFN-α) levels have been estimated from a total of 88 individuals of which 19 were disease-free healthy individuals, and 69 were patients with thyroid diseases: goitre (N = 21), autoimmune diseases (N = 16), and carcinomas (N = 32). Both IL-8 and IFN-α were significantly higher in all the patients as compared to healthy individuals. Serum IL-8 levels showed significant positive correlation with disease stage in thyroid cancer patients. Higher serum IL-8 levels were associated with advanced disease stage while no significant correlation was observed between serum IFN-α levels and any of the clinicopathological parameters. IL-8 and IFN-α significantly correlated with each other in anaplastic carcinoma patients. Finally concluding, monitoring the serum IL-8 and IFN-α levels can help differentiate patients with thyroid diseases from healthy individuals, and IL-8 seems to have a role in the pathogenesis of thyroid diseases and may represent a target for innovative diagnostic and therapeutic strategies.
- Subjects
THYROID diseases; INTERLEUKIN-8; INTERFERONS; THYROID cancer; CANCER patients; CARCINOGENESIS
- Publication
Journal of Thyroid Research, 2011, p1
- ISSN
2090-8067
- Publication type
Article
- DOI
10.4061/2011/270149