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- Title
PET imaging in a longitudinal non-Hodgkin's lymphoma study: association with tumor volume.
- Authors
Rossi M; Korkola P; Pertovaara H; Järvenpää R; Dastidar P; Wu X; Soimakallio S; Eskola H; Kellokumpu-Lehtinen PL; Rossi, Maija; Korkola, Pasi; Pertovaara, Hannu; Järvenpää, Ritva; Dastidar, Prasun; Wu, Xingchen; Soimakallio, Seppo; Eskola, Hannu; Kellokumpu-Lehtinen, Pirkko-Liisa
- Abstract
<bold>Background: </bold>Computed tomography (CT) is generally used in the evaluation of the treatment response of non-Hodgkin's lymphoma (NHL) patients. Instead of morphological images, positron emission tomography (PET) shows metabolic information that is connected to tumor activity, cell proliferation rate, and, thus, prognosis. <bold>Purpose: </bold>To determine the prognostic value of PET for tumor volume reduction measured by CT and magnetic resonance imaging (MRI) along with clinical characteristics in NHL patients. <bold>Material and Methods: </bold>We imaged 21 B-cell type NHL patients using whole-body 18F-FDG-PET at the onset and the completion of treatment and at six-month follow-up. The maximum standardized uptake value (SUV(max)) was calculated. Morphological tumor volume calculations were assessed using both MRI and CT. Additionally, patients underwent thorough clinical examination including several laboratory tests. <bold>Results: </bold>A high SUV(max) was able to predict significant tumor volume reduction at the beginning of treatment, but the relation to pure tumor volume was poor. <bold>Conclusion: </bold>The SUV(max) values derived from FDG-PET seemed to correlate with volume changes but not with their absolute values or laboratory tests. Unlike MRI and CT, FDG-PET showed the disappearance of active tumors after treatment.
- Subjects
TOMOGRAPHY; LYMPHOMAS; POSITRON emission tomography; CELL proliferation; MAGNETIC resonance imaging; TUMORS
- Publication
Acta Radiologica, 2011, Vol 52, Issue 9, p995
- ISSN
0284-1851
- Publication type
journal article
- DOI
10.1258/ar.2011.110099