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- Title
In-Stent Stenosis: Potential Role of Increased Oxidative Stress and Glutathione-Linked Detoxification Mechanisms.
- Authors
Misra, Praphul; Reddy, Pratap C.; Shukla, Deepti; Caldito, Gloria C.; Yerra, Lakshminarayan; Aw, Tak Y.
- Abstract
This study was designed to determine whether red-cell oxidative stress status and antioxidant enzyme levels can serve as markers in patients predisposed to in-stent stenosis. Blood was collected from patient groups undergoing coronary angiography for chest pain evaluation, namely, group A (without coronary artery disease), group B (previous coronary stents without in-stent stenosis), and group C (previous coronary stents with in-stent stenosis). Thiobarbituric acid reactive substances (measure of lipid peroxidation), glutathione-linked detoxification enzymes, catalase, and superoxide dismutase were determined. Compared with group A, patients in group C showed increased lipid peroxidation products and glutathione-S-transferase but decreased glutathione peroxidase and glutathione reductase activities. Results in group B patients were intermediate between those of groups A and C with significant decreases in glutathione peroxidase versus controls. In-stent stenosis is associated with significant increase in lipid peroxidation and attenuated glutathione-linked detoxification enzymes, consistent with oxidative stress.
- Subjects
STENOSIS; CORONARY disease; OXIDATIVE stress; ENZYMES; GLUTATHIONE; DETOXIFICATION (Alternative medicine); ANGIOGRAPHY
- Publication
Angiology, 2008, Vol 59, Issue 4, p469
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319707309651