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- Title
PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7.
- Authors
Perroy, J.; Far, O.EI; Bertaso, F.; Pin, J.P.; Betz, H.; Bockaert, J.; Fagni, L.
- Abstract
Both postsynaptic density and presynaptic active zone are structural matrix containing scaffolding proteins that are involved in the organization of the synapse. Little is known about the functional role of these proteins in the signaling of presynaptic receptors. Here we show that the interaction of the presynaptic metabotropic glutamate (mGIu) receptor subtype, mGlu7a, with the postsynaptic density-95 disc-large zona occludens 1 (PDZ) domain-containing protein, PICK1, is required for specific inhibition of P/Q-type Ca2+ channels, in cultured cerebellar granule neurons. Furthermore, we show that activation of the pre- synaptic mGIu7a receptor inhibits synaptic transmission and this effect also requires the presence of PICK1. These results indicate that the scaffolding protein, PICK1, plays an essential rote in the control of synaptic transmission by the mGlu7a receptor complex.
- Subjects
PROTEINS; NEURONS; CELLS; NERVOUS system; BIOMOLECULES; ORGANIC compounds
- Publication
EMBO Journal, 2002, Vol 21, Issue 12, p2990
- ISSN
0261-4189
- Publication type
Article
- DOI
10.1093/emboj/cdf313