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- Title
DERANGEMENT OF SERUM BIOCHEMICAL MARKERS OF RENAL FUNCTIONS IN HYPERTHYROID NON-PREGNANTWOMEN.
- Authors
Shah, Jasmine; Jan, Muhammad Rasul; Yousaf, M. M.
- Abstract
Aim and objective: This hospital based cross sectional study was carried out to study the effect of hyperthyroidism on the serum biochemical markers of renal function in non-pregnant women in Khyber Pakhtunkhaw. Background: Thyroid Hormones (TH) play a very important role in growth, development and functions of the kidney. This present cross-sectional study was carried out to generate a data about thyroidal hyper function and its ill effects on the biochemical markers of renal functions in Non-pregnant Women (NPW) of Khyber Pakhtunkhwa in Northern Pakistan. Material and Methods: The study was conducted on 163 non-pregnant women in the age group of 18-75 attending various outpatient departments in Khyber Teaching Hospital (KTH) of Khyber pakhtunkhaw. Serum T3 and T4 analysis was performed using competitive ELISA technique and serum TSH was performed using sandwich ELISA technique. Serum urea was measured by kinetic method and Serum creatinine by modified Jaffe method. Results: Mean serum creatinine was highest in normal (N) group (1.47±1.25 mg/dl) as compared to Overtly Hyperthyroid (OH) (1.29±0.01 mg/dl) and sub clinically Hyperthyroid (SH) group (1.34±0.15 mg/dl). Mean Serum Urea level was found elevated in OH (35.35±1.75 mg/dl) and SH (32.98±1.63 mg/dl) as compared to N group (32.60±1.22 mg/dl). Serum creatinine showed positive relation with TSH, in all the study groups, negative with T3 in N group, OH group and positive in SH group. Serum creatinine showed a significant positive correlation with TSH in OH group (p= 0.05). Serum creatinine showed a significant negative correlation with T3 in N group (p= 0.05). No significant correlation with T4 was found either for creatinine or Urea in any of the study groups.
- Subjects
PAKISTAN; HYPERTHYROIDISM; WOMEN'S health; WOMEN; PUBLIC health; ENZYME-linked immunosorbent assay; PATIENTS
- Publication
Medical Channel, 2016, Vol 22, Issue 2, p57
- ISSN
1681-5491
- Publication type
Article