We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Sulfonated (1→6)-β-D-Glucan (Lasiodiplodan): Preparation, Characterization and Bioactive Properties.
- Authors
Cristina Calegari, Gabrielle; Queiroz Santos, Vidiany Aparecida; Barbosa-Dekker, Aneli M.; Busso, Cleverson; Dekker, Robert F. H.; Alves da Cunha, Mário Antônio
- Abstract
Sulfonated derivatives of lasiodiplodan (LAS-S) with different degrees of substitution (1.61, 1.42, 1.02 and 0.15) were obtained and characterized by Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermal and solubility analyses. Antimicrobial, antioxidant and cytotoxic potential were also assessed. The sulfonation was confirmed by FTIR analysis with specific bands at 1250 cm-1 (S=O, strong asymmetrical stretching vibration) and at 810 cm-1 (C-O-S, symmetrical vibration associated with the C-O-SO3 group) in the sulfonated samples. SEM demonstrated that sulfonation promoted morphological changes on the surface of the biopolymer with heterogeneous fibrillary structures appearing along the surface following chemical modification. LAS-S showed high thermal stability, with mass loss due to oxidation at temperatures close to 460 °C. Sulfonation increased the solubility of LAS, and in addition, increased the antimicrobial activity, especially against Candida albicans (fungicidal) and Salmonella enterica Typhimurium (bacteriostatic). Native lasiodiplodan (LAS-N) showed higher OH? removal capacity, while LAS-S had higher ferric ion reducing antioxidant power (FRAP) potential. LAS-N and LAS-S did not demonstrate lethal cytotoxicity against wild and mutant strains of Saccharomyces cerevisiae. Samples with higher degree of substitution (1.42 and 1.61) showed lower potential to induce oxidative stress.
- Subjects
SALMONELLA enterica serovar typhimurium; IRON ions; SCANNING electron microscopy; INFRARED spectroscopy; SULFONATION; CANDIDA albicans
- Publication
Food Technology & Biotechnology, 2019, Vol 57, Issue 4, p490
- ISSN
1330-9862
- Publication type
Article
- DOI
10.17113/ftb.57.04.19.6264