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- Title
The effect of hypoxia and work intensity on insulin resistance in type 2 diabetes.
- Authors
Mackenzie R; Elliott B; Maxwell N; Brickley G; Watt P; Mackenzie, R; Elliott, B; Maxwell, N; Brickley, G; Watt, P
- Abstract
<bold>Context: </bold>Hypoxia and muscle contraction stimulate glucose transport in vitro. We have previously demonstrated that exercise and hypoxia have an additive effect on insulin sensitivity in type 2 diabetics. <bold>Objectives: </bold>Our objective was to examine the effects of three different hypoxic/exercise (Hy Ex) trials on glucose metabolism and insulin resistance in the 48 h after acute hypoxia in type 2 diabetics. <bold>Design, Participants, and Interventions: </bold>Eight male type 2 diabetics completed 60 min of hypoxic [mean (sem) O(2) = ∼14.7 (0.2)%] exercise at 90% of lactate threshold [Hy Ex(60); 49 (1) W]. Patients completed an additional two hypoxic trials of equal work, lasting 40 min [Hy Ex(40); 70 (1) W] and 20 min [Hy Ex(20); 140 (12) W]. <bold>Main Outcome Measures: </bold>Glucose rate of appearance and rate of disappearance were determined using the one-compartment minimal model. Homeostasis models of insulin resistance (HOMA(IR)), fasting insulin resistance index and β-cell function (HOMA(β-cell)) were calculated at 24 and 48 h after trials. <bold>Results: </bold>Peak glucose rate of appearance was highest during Hy Ex(20) [8.89 (0.56) mg/kg · min, P < 0.05]. HOMA(IR) and fasting insulin resistance index were improved in the 24 and 48 h after Hy Ex(60) and Hy Ex(40) (P < 0.05). HOMA(IR) decreased 24 h after Hy Ex(20) (P < 0.05) and returned to baseline values at 48 h. <bold>Conclusions: </bold>Moderate-intensity exercise in hypoxia (Hy Ex(60) and Hy Ex(40)) stimulates acute- and moderate-term improvements in insulin sensitivity that were less apparent in Hy Ex(20). Results suggest that exercise duration and not total work completed has a greater influence on acute and moderate-term glucose control in type 2 diabetics.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2012, Vol 97, Issue 1, p155
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2011-1843