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- Title
Adverse events of video capsule endoscopy over the past two decades: a systematic review and proportion meta-analysis.
- Authors
Wang, Yuan-Chen; Pan, Jun; Liu, Ya-Wei; Sun, Feng-Yuan; Qian, Yang-Yang; Jiang, Xi; Zou, Wen-Bin; Xia, Ji; Jiang, Bin; Ru, Nan; Zhu, Jia-Hui; Linghu, En-Qiang; Li, Zhao-Shen; Liao, Zhuan
- Abstract
<bold>Background: </bold>A full spectrum of video capsule endoscopy (VCE) adverse events over the past two decades has not been evaluated. We aimed to determine pooled rates, predictors and temporal-trend of VCE adverse events over the past two decades.<bold>Methods: </bold>Systematic search of PubMed and EMBASE for English-language publications reporting VCE adverse events (January 1, 2000 to March 31, 2019). Data were extracted independently by two investigators. Pooled VCE adverse event rates were calculated using the random or fixed model as appropriate. Predictors and temporal-trend of each adverse event were performed by meta-regression analyses.<bold>Results: </bold>In total, 402 studies were identified, including 108,079 VCE procedures. Rate of retention, swallow disorder, aspiration, technical failure, and procedural adverse events were 0.73% (95% confidence interval [CI] 0.59-0.89%), 0.75% (95% CI 0.43-1.13%), 0.00% (95% CI 0.00-0.00%), 0.94% (95% CI 0.65-1.28%), 0.67% (95% CI 0.32-1.10%), respectively; incomplete examination rate of esophagus, stomach, small bowel, and colon were 9.05%, 7.69%, 12.08%, 19.19%, respectively. Patency capsule reduced retention rate by 5.04%, whereas known inflammatory bowel disease increased retention rate by 4.29%. Elder was the risk and protective factor for small bowel incomplete examination (0.30%) and swallow disorder (- 0.72%), respectively. Rates of retention and small bowel incomplete examination significantly declined over time (P = .0006 and P < .0001)..<bold>Conclusions: </bold>VCE adverse event rates were generally low, and retention and small bowel incomplete examination rates declined over the past two decades. Patients with known inflammatory bowel disease or elder should be alerted to high risk of retention or small bowel incomplete examination (PROSPERO: CRD42019139595).
- Subjects
CAPSULE endoscopy; INFLAMMATORY bowel diseases; OLDER people; RISK retention; COLON (Anatomy); RESEARCH; META-analysis; RESEARCH methodology; SYSTEMATIC reviews; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; SMALL intestine; RESEARCH funding
- Publication
BMC Gastroenterology, 2020, Vol 20, Issue 1, p1
- ISSN
1471-230X
- Publication type
journal article
- DOI
10.1186/s12876-020-01491-w