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- Title
Synthesis and Biological Evaluation of Novel Chalcone-Porphyrin Conjugates.
- Authors
Serra, Vanda Vaz; Camões, Fátima; Vieira, Sandra I.; Faustino, Maria A. F.; Tomé, Joao P. C.; Pinto, Diana C. G. A.; Neves, Maria G. P. M. S.; Tomé, Augusto C.; Silva, Artur M. S.; da Cruz e Silva, Edgar F.; Cavaleiro, José A. S.
- Abstract
Studies on the synthesis, structural characterization and biological evaluation of novel chalcone-porphyrin derivatives are described. The photodynamic effect, intracellular localization and cellular uptake of the new conjugates were evaluated in vitro in COS-7 cells. All derivatives exhibited high stability and yielded good fluorescence under light irradiation. None of the chalcone-porphyrins proved to be cytotoxic and/or phototoxic for COS-7 cells.
- Subjects
PORPHYRINS; BIOSYNTHESIS; FLUORINE; FLUORESCENCE; IRRADIATION
- Publication
Acta Chimica Slovenica, 2009, Vol 56, Issue 3, p603
- ISSN
1318-0207
- Publication type
Article